Interaction of prostacyclin synthase with cytochromes P450
نویسندگان
چکیده
منابع مشابه
Interaction of aromatic cytokinins with human liver microsomal cytochromes P450.
Aromatic cytokinins (ortho-topolin riboside, 6-benzylaminopurine riboside and 6-(2-hydroxy-3-methoxybenzyla mino)purine riboside) were tested for their possible interaction with human liver microsomal cytochromes P450 by absorption difference spectroscopy. All three compounds were shown to bind to the CYP enzymes producing a high to low spin shift of the heme iron yielding a Soret absorption ba...
متن کاملInteraction of buprenorphine and its metabolite norbuprenorphine with cytochromes p450 in vitro.
Buprenorphine is a thebaine derivative used in the treatment of heroin and other opiate addictions. In this study, the selective probe reactions for each of the major hepatic cytochromes P450 (P450s) were used to evaluate the effect of buprenorphine and its main metabolite norbuprenorphine on the activity of these P450s. The index reactions used were CYP1A2 (phenacetin O-deethylation), CYP2A6 (...
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Omeprazole, lansoprazole and pantoprazole are metabolized by several human cytochromes P450, most prominently by CYP2C19 and CYP3A4. Only pantoprazole is also metabolized by a sulfotransferase. Differences in the quantitative contribution of these enzymes and in the relative affinities of the substrates explain some of the observed interactions with carbamazepin, diazepam, phenytoin and theophy...
متن کاملWhichCyp: prediction of cytochromes P450 inhibition
SUMMARY In this work we present WhichCyp, a tool for prediction of which cytochromes P450 isoforms (among 1A2, 2C9, 2C19, 2D6 and 3A4) a given molecule is likely to inhibit. The models are built from experimental high-throughput data using support vector machines and molecular signatures. AVAILABILITY The WhichCyp server is freely available for use on the web at http://drug.ku.dk/whichcyp, wh...
متن کاملCytochromes P450 in the bioactivation of chemicals.
The initial view that the cytochrome P450 enzyme system functions simply in the deactivation of xenobiotics is anachronistic on the face of mounting evidence that this system can also transform many innocuous chemicals to toxic products. However, not all xenobiotic-metabolising cytochrome P450 subfamilies show the same propensity in the bioactivation of chemicals. For example, the CYP2C, 2B and...
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ژورنال
عنوان ژورنال: Biomeditsinskaya Khimiya
سال: 2019
ISSN: 2310-6905,2310-6972
DOI: 10.18097/pbmc20196501063